Liposomal Encapsulation Delivers Medications More Efficiently

By Jody Leach


Drugs used to fight disease typically target specific physical systems or organs. Intravenous drips and injections are the most directly effective delivery method, transferring those medications directly to the blood. Orally administered drugs face degradation from the substances that accompany normal digestion. Liposomal encapsulation creates a protective bubble that wards off acids, while encouraging absorption.

Medical scientists first became aware of this process than fifty years ago, leading to the development of newer and more effective methods of drug delivery. The process is currently being used during treatment of serious conditions such as stubborn fungal infections, some kinds of cancers, and even age-related conditions leading to loss of vision. While standard medication delivery methods are still predominant, the encapsulation approach is also proving beneficial.

For drugs to survive the upper digestive tract intact, they need to be protected by some kind of barrier that does not cause any additional physical problems. The best solution so far is to create microscopic drug capsules using a material that is already a part of cellular walls throughout the human organism. When activated using one of three primary methods available today, tiny protective liposome bubbles are formed.

These individual capsules can be ingested together in a medium, and are shielded from damage until they can be absorbed into the bloodstream via the small intestine. In many cases this process improves the overall therapeutic goal, with the added benefit of fewer side effects. While a significant improvement, this method of delivery does not accommodate all drugs, and works best with water-soluble medications.

Because it involves fewer undesirable reactions than invasive delivery, there are immediate advantages of using this process. Liposomes are bio-compatible and biodegradable, leaving behind no undesirable toxins. They not only survive the onslaught of digestive acids, but are able to function as small time-release ports within the gut. When potentially toxic drugs must be used to fight cancers, fewer sensitive tissues face unwanted exposure.

Even though already proven effective through use, there is a slight down side. Production costs are significantly high, but will likely experience a decline as greater demand influences the market. Seal leakage has been reported in some cases, and oxidation sometimes reduces overall effectiveness. During the process some drugs have experienced a decline in their half-life, and stability issues have occurred, but positive benefits still predominate.

The past ten years have witnessed a transition from primarily medical use to include delivery of cosmetic and nutritional substances. There is ample anecdotal evidence touting the additional well-being that may result from delivering common vitamin dosages in this fashion. Many people subscribe to the idea that vitamin C is a natural enemy of upper respiratory infections, and also believe that this type of delivery increases effectiveness.

Although information highlighting consumer ability to create encapsulated vitamins, minerals, and even herbal extracts is readily available, making high-quality formulations can be costly and involved, and will not effectively combat the normal issues associated with aging. As support and development of this process continues in the medical world, the public will benefit most from it being used in conjunction with health regimens that have already been proven effective.




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