Extract of Reishi and Inflammation

By Dr. Markho Rafael


Reishi extract has been used in Traditional Chinese Medicine to treat arthritis and other forms of inflammation for over 2,000 years. Also commonly known by its Latin name as "Ganoderma," or Chinese "Ling Zhi," Reishi is by far the most searched medicinal mushroom on the Internet with over 200,000 searches per month. And although it may not be the panacea ("cure-all") that some hold it to be, the fact that modern research confirms it as an inflammation modulator may help explain why it has long been heralded as such in the Orient.

While researching scientific papers in preparation for this article, seventeen out of nineteen presented positive results in using Reishi extract to treat inflammatory conditions. This appears to validate the traditional use of the herb in China, where it has long been used as an analgesic, and prescribed to treat inflammation and arthritis. Only two studies out of the nineteen that are referenced for this article showed inconclusive results. Both of those studies were conducted at the same institution.

A U.S. based study conducted in 1993 showed that a water extract of Ganoderma lucidum (Reishi) exhibited "significant anti-inflammatory activity." Ten years later, an Indian research paper was published which stated that the use of Reishi extract helped decrease inflammation in acute edema by 56% and in chronic edema by 60%. Using the "Article References" link on this page, you will find references to seven additional research articles that confirm Reishi extract as a powerful anti-inflammatory agent.

Other research has been conducted on Reishi extract that relate specifically to arthritis. In 2006, Kenneth Blum et al. published findings in support of both the effectiveness and safety of using Reishi extract for "joint health," providing "clinical evidence" to back up their claim.

The same year, another study summarized findings that Reishi in combination with a Chinese herbal remedy known as San-Miao-San demonstrated a positive "immunomodulatory effect" on rheumatoid arthritis. (Immunomodulatory = helps to balance immune response.)

Just how Reishi accomplishes its beneficial influence on arthritis may have been stumbled upon by Ho et al. in 2007 when they discovered that GL-PP [Ganoderma lucidum polysaccharide peptide] helped to significantly reduce one of the causative agents of rheumatoid arthritis known as RASF, short for "Rheumatoid Arthritis Synovial Fibroblasts."

Five additional studies are included in the references that report positive findings between Reishi and arthritis. One goes so far as to state that Reishi shows favorable results when compared to prednisone (an arthritis-drug), and is free from the side effects. In extension of this, a separate study also found that not only was Reishi extract free of the side effects of prednisone, it could also help balance the existing side effects of prednisolone* such as cell toxicity and proteinuria. (*Prednisolone is the active compound of prednisone. The liver breaks down prednisone and converts it to prednisolone.)

In conclusion, the findings of 17 out of the 19 scientific papers referenced for this article agree that Reishi can help support joint health in cases of arthritis. However, it is important to always consult a licensed medical practitioner before using any herb for medicinal purposes, and to never change the use of existing prescription drugs without talking to your doctor about it first.

Note: "Reishi" is the Japanese name on the mushroom known in English as "Varnished Conk." It actually encompasses several closely related species, the most common of which is Ganoderma lucidum (Common Reishi or Red Reishi). This species can be found in the U.S. but is much more common in South East Asia. It is also well known by its Chinese name, Ling Zhi.

Several closely related species of Ganoderma also go by the name of "Reishi". Most common of these are the Hemlock Reishi (Ganoderma tsugae) found on Hemlocks in the Appalachian Mountains, and the Chinese species "Black Reishi" (Ganoderma sinense). Less common are Ganoderma resinaceum (sometimes called "Red Reishi," although that name is more often used for G. lucidum), Ganoderma neo-japonicum (no common name other than "Reishi"), and Ganoderma japonicum (Purple Reishi).




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